main article: Pharmacodynamics藥效動力學PD
A mode of action (MoA) is different from mechanism of action (MOA)(mechanism).
difference[]
- A mode of action (MoA)(作用模式) describes a functional or anatomical change, at the cellular level, resulting from the exposure of a living organism to a substance. In comparison, a
- mechanism of action(作用機轉)(機轉) (MOA)(mechanism) describes such changes at the molecular level.[1][2]
example[]
Ex. chemotherapy的Paclitaxel | Ex. Molecular Targeted therapeutic agents靶向治療藥品: Ex1. Ab-chemotherapeutic conjugates Ex2. Bevacizumab癌思停Avastin® | |
---|---|---|
Mode of action作用模式 | inhibition of cell mitosis | Ex2. Bevacizumab癌思停Avastin®:inhibition of angiogenesis |
mechanism of action作用機轉 | react with Tubulin | Ex2. Bevacizumab癌思停Avastin®:bind to VEGFR |
reference[]
wikipedia20170816