Mode of action作用模式 and mechanism of action作用機轉

main article: Pharmacodynamics藥效動力學PD

A mode of action (MoA) is different from mechanism of action (MOA)(mechanism).

difference

• A mode of action (MoA)(作用模式) describes a functional or anatomical change, at the cellular level, resulting from the exposure of a living organism to a substance. In comparison, a
• mechanism of action(作用機轉)(機轉) (MOA)(mechanism) describes such changes at the molecular level.

example

	Ex. chemotherapy的Paclitaxel	Ex. Molecular Targeted therapeutic agents靶向治療藥品: Ex1. Ab-chemotherapeutic conjugates Ex2. Bevacizumab癌思停Avastin®
Mode of action作用模式	inhibition of cell mitosis	Ex2. Bevacizumab癌思停Avastin®:inhibition of angiogenesis
mechanism of action作用機轉	react with Tubulin	Ex2. Bevacizumab癌思停Avastin®:bind to VEGFR

reference

wikipedia20170816